Gluconeogenesis in the perfused rat liver
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چکیده
منابع مشابه
Inhibition of gluconeogenesis by butylmalonate in perfused rat liver.
The role of mitochondrial anion exchange reactions in the control of gluconeogenesis in perfused livers from fasted rats was investigated by using Z-n-butylmalonate to inhibit malate transport across the mitochondrial membrane. Glucose production from pyruvate or lactate was inhibited 50% to 80% by 5 m&r butylmalonate. Oleate (0.5 or 1.5 mr+r) increased glucose production from pyruvate from 82 ...
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Communicated by B. Chance, May 6, 1966 The pathway of gluconeogenesis is distinguished from that of glycolysis by several enzyme reactions which overcome the energy barriers preventing a direct reversal of glycolysis.I These reactions are* catalyzed by pyruvic carboxylase, PEP-carboxykinase, fructose-1,6-diphosphatase, and glucose-6-phosphatase. Considerable emphasis has been placed on the poss...
متن کاملControl of gluconeogenesis from amino acids in the perfused rat liver.
Gluconeogenesis from amino acids was investigated with isolated rat livers perfused with Krebs bicarbonate buffer containing bovine red cells and serum albumin. In livers from fasted rats perfused with a mixture of amino acids at various multiples of their normal plasma concentrations, glucose production was half-maximal at normal amino acid concentrations and approached saturation at three tim...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1966
ISSN: 0006-2936
DOI: 10.1042/bj1010284